Building upon the latest normative recommendations and good practice statements from the World Health Organization (WHO), this guidance includes key considerations to support the introduction and scale-up of self-care interventions in countries, at the national or subnational level. In implementing the global recommendations on self-care interventions for health and well-being, countries will need to adapt them to the local context, considering the economic conditions and the existing health services and facilities. This guidance is intended to assist with that process. This guidance is relevant for all settings and should, therefore, be considered as global guidance.